Perlmutter Cancer Center researchers are investigating new therapies for multiple myeloma. For example, we discovered that several members of the "MAGE" family of cancer-associated proteins are very commonly expressed in multiple myeloma cells. We are currently developing several new treatment strategies designed to target MAGE proteins in myeloma. The first is a vaccine that will train the patient's own immune system to identify and kill MAGE-expressing myeloma cells. They are also investigating the function of MAGE proteins in myeloma cells, which may lead to the development of new drugs that will block these functions.
Our goal is to improve the outcome of treatment in multiple myeloma using targeted therapies that will have greater effectiveness and fewer side effects than conventional approaches.