Studies of Osteopontin

Perlmutter Cancer Center researchers have shown that osteopontin, a common protein associated with cancer metastasis and invasion, is an important biomarker in lung cancer. In a series of publications, the researchers have reported that osteopontin decreases after patients have potentially curative resection for lung cancer.

Moreover, they have found that there are different species (isoforms) of osteopontin which work in diametrically opposite directions. The lab is working to characterize these isoforms to find a sensitive and specific marker for lung cancer in the plasma, as well as to monitor patients' disease after treatment.